The Lyme and Tick-Borne Disease Research Centers at Columbia University Irving Medical Center
1051 Riverside Drive
New York, NY 10032
https://www.columbia-lyme.org


The Johns Hopkins Lyme Disease Research Center
2360 W. Joppa Rd
Lutherville, MD 21093
https://www.hopkinslyme.org


Division of Infectious Diseases, Children’s National Medical Center
111 Michigan Avenue, NW
Washington, District of Columbia 20010
https://childrensnational.org/departments/infectious-diseases


The University of California, San Francisco Lyme Clinical Trials Center
2540 23rd Street
San Francisco, CA 94110
https://ctsi.ucsf.edu/about-us/programs/clinical-research-services


SUNY Upstate Medical University
5010 Campuswood Drive Suite 100
East Syracuse, NY 13057
https://www.upstate.edu/globalhealth


The Cohen Center for Recovery from Complex Chronic Illness (CoRE)
Icahn School of Medicine at Mount Sinai
5 East 98th Street, SB Level, Room 18
New York, NY 10029


Lyme Clinical Trials Network Nodes

The Lyme and Tick-Borne Disease Research Centers at Columbia University Irving Medical Center

The Lyme and Tick-Borne Diseases Research Center (LTDBRC) at the Columbia University Irving Medical Center was established in 2007 as the first academic research center in the country to focus multidisciplinary research on the chronic aspects of Lyme and other tick-borne diseases, particularly neurologic and neuropsychiatric sequalae. This Center is committed to using the latest scientific tools to fight this rapidly spreading disease. The LTDBRC includes two core areas – clinical research and a national Clinical Trials Network for Tick-borne Diseases (CTN-LTD). The CTN will enhance the speed and quality of clinical trials on Lyme and TBD. The Lyme and Tick-borne Diseases Research Center will continue its commitment to clinical research (diagnostics, biomarkers, treatment) and to training through the provision of educational fellowships for the next generation of clinicians.

The Johns Hopkins Lyme Disease Research Center

The Johns Hopkins Medicine Lyme Disease Research Center was established in 2015 where it is part of the Department of Medicine. The Hopkins Lyme Center continues the tradition of promoting fundamental and translational research started by our forbearer Sir William Osler the first head of Medicine at Johns Hopkins. The Center’s current research programs are focused on advancing the understanding of biologic disease mechanisms and on improving the accuracy of diagnostic tests for both acute and chronic presentations of Lyme disease. The Center’s integration with the Division of Rheumatology enhances its research into the immune mechanisms that may drive persistent symptoms in Lyme disease.

Division of Infectious Diseases, Children’s National Medical Center

As one of the country’s leading children’s hospitals, the Children’s National Hospital provides compassionate, world-class care and research. The Children’s National Lyme and other tick-borne disease program is prioritizing study of the risk of maternal-fetal transmission and surveillance for potential complications (e.g., brain development); this research will help to inform treatment strategies for pregnant women. Children’s National continues to partner with the federal HHS Lyme Innovation initiative to accelerate innovation in the prevention, diagnosis and treatment of tickborne diseases. In 2017, Children’s National partnered with the NIAID to advance the health of children with infectious diseases (e.g, Lyme disease) to identify key factors associated with recovery or longer term symptoms.

The University of California, San Francisco Lyme Clinical Trials Center

The University of California, San Francisco (UCSF) Lyme Clinical Trials Center (CTC) was established in 2022 and is funded by the Bay Area Lyme Foundation. The Center integrates personnel and expertise from the UCSF Departments of Laboratory Medicine and Neurology to initiate and support multiple clinical trials for diagnosis and/or treatment of Lyme Disease and other tick-borne infections. In 2023, the UCSF Lyme CTC officially joined Columbia University’s Clinical Trials Network, becoming the network’s first West Coast node.

SUNY Upstate Medical University

SUNY Upstate Medical University is an academic medical center that delivers patient-centered health care that addresses our region's most pressing concern by educating health professionals and conducting research that improves our understanding of health and disease. As a public university, our regional influence is broad, serving a large swath of central New York. The Infectious Disease Division provides care for Lyme and other tick borne diseases and was recently awarded funding to further develop a multidisciplinary clinic to help address these growing threats. The Global Health Institute is a research, public health institute with one central focus of developing products for diseases of the developing world. It incorporates the efforts and programs of both basic science researchers and clinical investigators across the entire continuum of translational research. The Institute has partnerships with the Department of Defense, industry, academic institutions, and philanthropists; raises research funds; conducts novel research and develops new diagnostics, drugs, and vaccines (including first-in-human through Phase 4). The Institute recently joined the Lyme CTN as a platform for performing much needed Lyme and TBD research in Central New York.

The Cohen Center for Recovery from Complex Chronic Illness at the Icahn School of Medicine at Mount Sinai

The Cohen Center for Recovery from Complex Chronic Illness (CoRE) is a hybrid clinical and research center for people living with post-acute infection syndromes (PAIS), including but not limited to Long COVID, Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and Chronic Lyme Disease. Located in the Department of Rehabilitation and Human Performance at the Icahn School of Medicine at Mount Sinai in New York City, its research program addresses the role of persistent pathogens and coinfections in PAIS and aims to support the translation of experimental paradigms into common clinical practice. CoRE is determined to offer patients with PAIS a better future through next generation interventions and world-class research.